This article presents an example of two boys who have received a list of diagnoses including Attention Deficit Hyperactivity Disorder (ADHD), autism, Asperger's syndrome, Oppositional Defiant Disorder (ODD), and clinical depression. Both boys received a variety of interventions ranging from behavior modification plans to counseling and medication, but it was not until their behaviors were examined from a sensory integration perspective that a clear, consistent picture of each of them began to emerge. Sensory integration (SI) is neurobiological activity within our bodies, defined as the way the central nervous system processes information from the senses. Sensory integration is the brain and nervous system's ability to organize the sensory information that bombard a person's nervous systems. When sensations flow into the brain in an organized or integrated manner, these sensations can be used by an individual to form perceptions and create learning experiences. Dysfunction occurs when the nervous system is unable to integrate incoming information smoothly, resulting in the misinterpretation of information and roadblocks to creating appropriate perceptions, behaviors, and learning experiences. In this article, the authors explain how sensory integration affects behavior and the interventions to promote sensory integration for all children. (Contains 1 table.)