There are a number of compelling reasons that justify attention to and implementation of non-familial adult participation in the lives of youth, through mentoring and intergenerational activities and programs. This article describes the rationale for activities that connect youth and older non-familial adults together in meaningful and productive relationships. Mentoring and intergenerational programs address specific developmental needs of at-risk children and youth. Both intergenerational and mentoring relationships within both spontaneous and programmatic contexts offer an array of formats that can encourage adults to serve as positive, strength-building influences in youths' lives and futures. This article offers suggestions for design and implementation of effective mentoring and intergenerational programs.