Professional development school (PDS) contexts are increasingly being viewed as powerful sites for the preparation of future teachers in the USA. One of their documented strengths is in the fostering of preservice teachers' inquiry within collaborative frameworks that result from the partnerships between university teacher education programmes and schools. This article focuses on one inquiry-based PDS programme, describes five inquiry projects carried out by interns in the programme, and presents interns' perceptions on engaging in inquiry during their yearlong internship. The discussion that follows explores the potential of the inquiry approach in PDS contexts to reform the teacher education practicum.