The swiftly growing field of neurobiological research utilizes highly advanced technologies (e.g., magnetic resonance imaging, electron microscopy) to mediate between investigators and the brains they investigate. Here, the author analyzes a device called the "slam freezer" that quick-freezes neurons to be studied under the microscope. Employing insights from Don Ihde's philosophy of technology, work that carefully amalgamates continental philosophy with philosophy of science, the author draws out the practices of interpretation in slam-freezing research. This interdisciplinary approach to understanding scientific methodology sets the stage for further philosophical investigation of research in neuroscience.