Background: Interest in the concept of quality of life (QOL) as a category guiding the development and provision of services for individuals with intellectual disabilities (ID) in Poland is increasingly being observed. Its presence in rehabilitation and care is strongly associated with the assessment of importance and use of QOL domains and indicators by Polish professionals. Method: The present study examined the differences related to selected demographic variables in the assessment of importance and use of eight QOL domains made by professionals in Poland working with persons with ID. Results: The evaluation of the importance and use of eight QOL domains and their indicators is related significantly to professionals' level of education, place of work, and total years of work. Conclusions: The perception of professionals cannot be overlooked when considering the development and provision of QOL-related services and supports.