The Republic of Moldova proclaimed its independence in 1991. Like other republics of the former USSR, during the last decade of the Twentieth Century, Moldova initiated social and economic reforms aimed at the country's transition to a market economy. A series of relevant social changes were achieved in Moldova but, contrary to initial estimates, they failed to provide the expected results. Moreover, this phase led to a deepening economic crisis, and subsequently to a catastrophic decline in living standards, the depreciation of moral and ethical norms, and insecurity. The departure of a large part of the labour force abroad, in search of jobs, has considerably diminished Moldova's human resources. Year by year, the emigration of the country's intellectuals has intensified. More and more higher education graduates, academics, school teachers and scientific researchers emigrate. No systematic and detailed studies of brain drain in Moldova exist, as the phenomenon has not been monitored at national level. The present study attempts a brief analysis of brain drain from the Republic of Moldova and offers some recommendations.