School counselors often experience burnout in their multifaceted roles. Extant literature has identified the relationship between school counselors' self-efficacy and burnout, but there is a paucity of literature regarding the relevance of mindfulness to school counselors' occupational self-efficacy and burnout. Through multiple regression, we examined the relationships between mindfulness, occupational self-efficacy, and burnout with a sample of 102 practicing school counselors in the United States. Our findings indicated that higher levels of mindfulness and occupational self-efficacy statistically significantly predicted lower levels of school counselors' burnout. We provide implications for practicing school counselors, counselor education and supervision, and future research.