We describe a game and teachers' experiences using it in their middle and high school science courses. The game, which is called "Luck of the Draw", was designed originally to engage medical students and later adopted for middle school, high school, and college students in genetics, and to encourage critical thinking about is-sues such as genetic engineering. We introduced the game to high school science teachers attending a summer workshop and asked them to describe their initial impressions of the game and how they might use it in their classes. We also asked middle and high school students about their experiences playing the game. Results indicated that teachers and students enjoyed the game and identified positive outcomes, including greater engagement and critical thinking. Further, the few potential problems that teachers initially thought might be encountered appeared to occur infrequently; ways to minimize these problems are discussed.