Educators are increasingly looking to neuroscience for guidance to improve classroom instruction and to teach their students about the nervous system. Although materials to assist teachers are available, many educators still have misconceptions about the brain. Twenty-three middle school teachers were trained to use the Sowing the Seeds of Neuroscience (neuroseeds.org) curriculum in their sixth, seventh, and eighth grade classrooms. The novel, hands-on, interactive lessons are aligned with Next Generation Science Standards and Common Core standards. The curriculum uses the "5E" model of instruction to study the neuroactive properties of plants and increase students' neuroscience literacy. The lessons are designed to be culturally responsive by encouraging students to bridge their home and school experiences through an examination of medicinal plants used by their families, communities, and/or ancestors. Student pretest-posttest (N=1,240) results revealed that students significantly improved their neuroscience content knowledge after participating in the Sowing the Seeds of Neuroscience curriculum program. These findings suggest that this curriculum program is a promising resource for middle school educators who want to improve their students' neuroscience literacy.