Interventions that build compassion for others may help increase social connectivity, combat loneliness, and promote positive adjustment in youth. However, limited research has examined the effects of this type of intervention on youth well-being. The goal of this small open pilot study was to examine the feasibility, acceptability, and outcomes of Inspiring Comfort, a 12-session group program in which youth learn and practice compassion, empathy, and helping others in distress. The program was implemented virtually during the COVID-19 pandemic with a sample of 10 students (ages 11 to 14) attending a non-profit special education school. Following the program, reductions in child-reported loneliness, depressive symptoms, and social anxiety were observed, along with increases in compassion for others and self-compassion. Students reported high satisfaction with the program, though challenges with the virtual format were noted. Findings suggest that a compassion-focused intervention may hold promise for addressing loneliness and internalising symptoms in youth, though randomised controlled trials with larger samples are needed.