This paper analyses the EU's approach to international research cooperation between 2012-2022 drawing on critical geopolitical perspectives and the spatial politics of (re)bordering. It identifies two periods which represent the EU's shifting approaches to international research cooperation from the pursuit of a liberal agenda promoting "openness" towards "selective closure" and a focus on ideological differences, regional interests and protectionism. This shift, we argue, was prompted by the changing geopolitical environment, marked by escalating tensions and perceived threats to the EU's economic stability, global position, security, and normative values. These factors spurred a re-evaluation of the EU's approach to international research cooperation, and a (re)bordering of its research space. We suggest that the EU began with utopian visions about the possibilities of neoliberal globalisation, open societies and economic collaboration and ended up withdrawing to a more closed and protectionist position in response to increasing external and internal threats, such as the aggressive actions of Russia in Ukraine, cyber-attacks by China, and the undermining of academic freedom in member states such as Hungary. This analysis contributes to understanding the relationship between geopolitics, higher education, and international research cooperation, highlighting the impact of a changing geopolitical environment on scientific cooperation in Europe.