The college experience can significantly increase feelings of anxiety in all students, as students find themselves in evaluative settings where academic, and often social abilities, are judged. Moreover, high levels of anxiety can lead to significant difficulties with navigating the challenges of college. For students with autism symptomatology, an elevated predisposition to feel anxious (i.e., trait anxiety) may cause more difficultly in successfully adjusting to college and succeeding academically. Thus, we examined differences in trait anxiety and college adjustment between cisgender women with and without autism symptomatology. We also explored the extent to which autism symptomatology and trait anxiety uniquely accounted for variance in college adjustment in women. Study findings showed that higher levels of autism symptomatology were associated with elevated trait anxiety. Additionally, both autism symptomatology and trait anxiety were associated with lower adjustment to college across four indices (academic, social, personal-emotional and total adjustment), although neither predicted GPA. We conclude with implications of our findings and recommendations for professionals serving autistic students, including disability resource officers.