This conceptual article introduces an innovative career development framework that integrates a focus on the social determinants of health within career development and postsecondary readiness counseling. This article provides an overview of career development and postsecondary readiness in schools, reviews the existing literature base on social determinants of health and school counseling, introduces the Career Development and Social Determinants Framework (CDSD-F), and lists implications for school counselors and counselor educators.