The State of Nevada launched the "Nevada SafeVoice" anonymous tip line to prevent harmful events in schools and to promote student safety, health, and wellbeing. We assessed the extent to which "SafeVoice" contributed to reductions in school discipline incidents, youth suicides, and increases in the positive school climate. Using interrupted time-series analyses, we found statistically significant reductions in the rates of violence against staff (an estimated 32% reduction across the two school years) and possession of weapons (also 32%). Comparing annual data over time, we also found significant improvements in school climate during the study period from 2018 to 2019. We found no effects of "SafeVoice" on incident rates of bullying, cyberbullying, violence against students, or suicides among youth. We estimated that savings associated with the prevented incidents of violence against staff and weapons possession totaled $34 million. Every dollar spent on the State's operation of "SafeVoice" saved $13.80 in identifiable prevented events, including $3.45 in direct out-of-pocket costs.