The partnership explored in this article offers a high-level view of one university-based research + practice partnership (RPP) with a local informal science institution (ISI) that suggests implications for advancing science education in various contexts. Touching K12 schools, undergraduate coursework, K12 teacher preparation, undergraduate career exploration opportunities, graduate-level research opportunities, public, and collaboration with content-area faculty members, the NExUS-Mississippi RPP offers an example of institutional agility necessary to advance equitable outcomes in science education across a variety of contexts. By honoring the inherent entanglement of communities and educational institutions, enacting an emergent strategy offers new avenues for characterizing partnership capacity-building efforts, organizational resilience, and sustainable design. Specifically, three thematic values consistently surface in the daily work of creating the conditions necessary for partnership persistence: (a) formalizing systems for stability, (b) building trust through transparent and frequent communication, and (c) creating mechanisms of implementation that can be replicated at other universities regardless of financial support.