Teachers who work with students with disabilities may have high levels of mental health problems, such as burnout or stress. The aim of this systematic review was to summarise the evidence on mental health outcome assessments among teachers of students with disabilities in different work spaces and to compare the levels of burnout and stress among teachers from general/regular versus special schools. The results reveal high levels of symptoms of burnout or stress in teachers of students with disabilities, regardless of the type of school. Due to the heterogeneity and low quality observed across the studies, evidence remains unclear.