Teachers' well-being and a conducive home learning environment play a pivotal role in improving children learning outcomes, but little is known about this in a humanitarian setting. This article assesses the role of teachers' well-being and home learning environment on children learning outcomes in Afghanistan. A cross section endline survey was conducted among 1407 primary school children, 1407 parents and 315 teachers in seven provinces of Afghanistan. Population-based two stage-cluster sampling was used. Children taught by teacher's who received professional development support were 3.19 and 4.0 times more likely to attain higher literacy and numeracy levels. Children taught by teachers with adequate teaching and learning materials were 1.60 and 1.83 times more likely to achieve higher literacy and numeracy levels. Children from teachers with ability to voice up and be consulted by school management attained higher social-emotional learning competencies. Children experiencing violent home learning environment had lower odds of achieving higher literacy, numeracy, and social-emotional learning competencies. Children with parents that helped them with learning were 1.85 and 1.94 times more likely to have higher literacy and numeracy levels. There is scope for public sector and development partners to promote a package of interventions aimed at promoting teacher's professional development, provision of teaching and learning materials, teacher recognition and voice to improve children's literacy, numeracy, social and emotional learning skills. Parents need to ensure a safe and conducive home learning environment. Parent should be actively involved in children's learning activities to nurture strong parental-child bond and parental-school partnership.