Active learning strategies engage students productively in the process of learning through problem-solving activities and discussions, over and above the routine method of listening passively to the instructor. This work highlights the redesign of a medicinal chemistry course by augmenting traditional lectures with active learning sessions in order to engage students in higher-order cognitive skills and promote student engagement. A combination of constructive and interactive activities was designed to incorporate three modes of interaction for the students: with the course content, with other students, and with the instructor. Analysis of student survey results provided valuable insights into the perceived effectiveness of active learning strategies on student engagement. Our students reported that they enjoyed participating in these sessions and perceived that they had a positive influence on their understanding of the course material. They also felt that they had been focused and appreciated the valuable contributions made by their peers. Overall, this report on our positive experience with active learning pedagogy in a medicinal chemistry course will guide faculty and other instructors as they design their courses to achieve student engagement.