Objective: The present study identified student characteristics associated with using protective behavioral strategies (PBS) to reduce harms when consuming alcohol. Participants: 224 college students who drink alcohol (66.5% female, 89.7% White non-Hispanic, Mage = 21.04) completed an anonymous study survey. Methods: Participants reported use of three PBSs: serious harm reduction; stopping or limiting drinking; and manner of drinking. They also reported sensation seeking, romantic involvement, parent-student alcohol communication, and attitudes toward alcohol in college life. Results: Attitudes toward alcohol in college life, Greek life participation, and sensation seeking were the variables most consistently associated with PBS use. Perceiving alcohol as an important part of college and sensation seeking were associated with less PBS use, but Greek life participation was associated with greater PBS use. Conclusions: Specific resources may be needed to encourage PBS use among high sensation seeking students and those who believe alcohol is a part of college life.