Objective: To identify social determinants of mental health embedded within college students' living and learning conditions. Participants: Participants included 215 mostly undergraduate (95%) business students at a diverse, urban west coast public university (48% women; mean age 24). Methods: Participants completed an online self-report survey measuring affective state, global mental health, anxious and depressive symptoms, as well as social determinants of mental health. Data were analyzed using multiple regression controlling for self-esteem, gender, and race/ethnicity. Results: Results suggest that higher family income is positively related to mental health, whereas more adverse events (e.g., assault, robbery, serious illness or injury), food insecurity, and commute time are negatively related to mental health. Moderation results indicate a moderate buffering effect of belonging on global mental health among students who experience zero adverse events. Conclusions: Social determinants can shed light on student's precarious living and learning conditions and resultant effects on students' mental health.