Problem-Based Learning (PBL) is an effective teaching method in many fields, in particular the medical disciplines. Clinical embryology deals with all aspects of assisted conception including insemination and embryo transfer. Clinical embryologists deal with daily issues that require troubleshooting and problem solving. The aim of this study was to explore and share the use of PBL teaching in a clinical embryology training programme. Students were given real-case scenarios and tasked with formulating a solution. A survey of questions to evaluate the PBL session was developed using a 5-point Likert scale. The scores obtained from these tests were assessed and analysed using Mann-Whitney U-tests (p = 0.05). The PBL teaching offered a format for students to develop critical problem-solving skills in a safe environment, which encourages learning through problem solving by creating a usable body of knowledge and clinical skill, which are imperative for clinical practice.