People who hold multiplicistic (multiplist) epistemic beliefs about science tend to believe that scientific knowledge is always subjective and that varying opinions on a scientific matter are equally valid. Research suggests that multiplist epistemic beliefs may be maladaptive and lead to a radically subjective view of science. Little is known about the association between such beliefs and mistrust in science/scientists and the tendency to believe in misinformation. The aims of this study were to examine: (a) the degree to which multiplist epistemic beliefs about science are associated with COVID-19 conspiracy beliefs and science-related conspiracy beliefs, (b) the degree to which trust in science mediates the association between multiplist epistemic beliefs about science and conspiracy beliefs, and (c) the extent to which COVID-19 conspiracy beliefs and science-related conspiracy beliefs are associated with compliance with COVID-19 prevention guidelines. Participants were 210 undergraduate students attending a Hispanic-serving institution located in a large city in the southern U.S. Path analysis results indicated that multiplist epistemic beliefs about science were positively associated with science-related conspiracy beliefs after accounting for fundamentalism and conservatism. Moreover, trust in science mediated the positive association between multiplist epistemic beliefs about science and COVID-19 conspiracy beliefs. Finally, belief in COVID-19 conspiracies was negatively associated with COVID-19 prevention guideline compliance.