Introduction: There is limited evidence on the impact of simulation learning with standardized patients and the affects occupational therapy and physical therapy students' attitudes toward interprofessional teams and the team approach to care. Methods: The current study investigated the Students' Perceptions of Interprofessional Clinical Education-revision 2 (SPICE-R2) from the archived data from a total of 248 physical therapy and occupational therapy students. Post-test scores were compared using an analysis of covariance with the pretest SPICE-R2 score as a covariate. Results: A statistically significant increase was found for the total SPICE-R2 and Teamwork subscore. No statistically significant difference was found for the Roles and Outcomes subscores. Conclusion: The use of simulation with health science graduate students is one method of teaching delivery to improve students' self-assessment of attitudes of interprofessional collaboration and team delivery of healthcare.