Objective: We employed latent profile analysis (LPA) to discern configurations of executive functioning (EF) and neuroticism (NE) and tested their concurrent validity with respect to internalizing and externalizing problems and physical health. Participants: A total of 125 college students completed the study. Methods: Participants self-reported NE and EF on separate normed rating scales and completed computerized tests of EF. Self-reported internalizing problems, externalizing problems, and global physical health were collected. Results: LPA revealed four profiles: (1) Lower EF + Higher NE, (2) Higher EF + Lower NE, (3) Inconsistent EF + Higher NE, and (4) Inconsistent EF + Lower NE. Adjusting for covariates, profiles were differentially associated with internalizing problems, externalizing problems, and physical health. Conclusions: Screening EF and NE in college students may identify those at risk for psychopathology and physical health concerns. Tailored prevention and intervention efforts on college campuses targeting EF and NE may enhance well-being.