The COVID-19 pandemic revealed how much the science education community has yet to understand about myriad variables that impact accurately informed socioscientific issue decision-making. Toward that end, this study investigated 415 university biology students' COVID-19 behaviours and opinions regarding how COVID-19 mandates might be associated with their views about COVID-19 science and scientists, risk perceptions, race/ethnicity, gender, and political orientation. Science-supported actions and mandate support were more highly exhibited by Asian and Black non-Hispanic and Hispanic students compared to White non-Hispanic students. Science supported actions and mandate support were also significantly associated with increased COVID-19 risk perceptions and knowledge and confidence about COVID-19 science. Higher levels of political conservatism was significantly associated with lower levels of COVID-19 mitigating actions and mandate support. Political orientation appeared to mediate the relationship between views about COVID-19 science, COVID-19 actions, and mandate support. These and other findings demonstrate that cognitive and sociocultural factors associated with socioscientific decision-making are complex and vary across contexts. An implication of this study is that efforts to promote a pragmatic science literacy for accurately informed SSI decision-making will require multivariate and synergistic approaches.