This study explored the relationship between multicultural distress and general stress symptoms and the academic achievement of college students attending a Minority-Serving Institution (MSI). Research suggests that students who identify as being from a racial or ethnic minority background are likely to experience multicultural distress. Such students are believed to be at greater risk of experiencing mental health and academic challenges. Many contend that being in a diverse learning setting serves as a protective factor, shielding racial/ethnic minority students from some degree of distress and thereby promoting mental health and academic well-being. In contrast, other research findings suggest that multicultural distress threatens mental health and academic well-being even within diverse minority-serving institutions. This paper seeks to understand better how multicultural distress relates to mental health and academic achievement among students from racial/ethnic minority backgrounds attending an MSI.