Research has demonstrated positive impacts of behavioral interventions on various educational outcomes for autistic youth, and implementation of these interventions in education settings has been widely advocated. However, recent studies have identified methodological shortcomings in the behavioral intervention evidence base, including lack of reporting on side effects and social validity. This review including 98 studies identified as evidence-based practices by the National Clearinghouse on Autism Evidence and Practice further highlights the lack of evaluation of side effects and social validity in behavioral intervention research. Suggestions are given regarding assessment of side effects, embedding social validity into intervention, and practical takeaways for educators. Future research and practice should prioritize addressing potential side effects and advancing ethical implementation of evidence-based behavioral interventions.