The purpose of this study was to explore potential effects of a 12-week therapeutic mentoring program targeting social, emotional, and behavioral concerns in 52 children and adolescents between 11 and 17 years of age. Self-reported scores on a norm-referenced behavioral questionnaire were tracked across the span of a mentoring program, and then analyzed using multilevel modeling. Results showed that participant scores changed in a healthy direction across all domains measured (i.e., conduct, negative affect, cognitive/attention, and academic functioning). Predictors in the multilevel model included caregiver-reported sex assigned at birth, the semester that the intervention took place, and whether a participant had repeated the program. Findings lend further support to research-based mentoring programs as effective community interventions to address behavioral, emotional, social, and academic concerns in youth.