The objective of this study is to determine the impact of entrepreneurship and digital literacy on the inclination of college students to initiate their own business ventures. Furthermore, the study aims to examine the role of business attitude and self-efficacy as mediators and moderators. The data utilized in this investigation was sourced from a sample of 536 authentic individuals and only pertains to Indonesia. The acquired data is analyzed using partial least squares structural equation modeling to evaluate the research model. The findings indicate that possessing a creative mentality, receiving formal education in entrepreneurship, and demonstrating proficiency in technology can significantly enhance an individual's inclination to embark on an entrepreneurial endeavor. Moreover, the entrepreneurial mindset serves as a bridge between the acquisition of business knowledge with the desire to become an entrepreneur. The results indicate that self-efficacy has a positive impact on the relationship between the aspiration to become an entrepreneur and having an entrepreneurial mindset. The unexpected finding revealed that self-efficacy diminishes the link between acquiring knowledge about entrepreneurship and the inclination to establish a business. Moreover, the results suggest that self-efficacy does not modify the correlation between digital knowledge and the inclination to start one's own business. The findings of the study have important implications for both the theoretical comprehension and practical execution of establishing and achieving company objectives.