This study examines the success and role of African women leaders in science, technology, engineering, and mathematics (STEM). In the absence of significant research on women's STEM leadership, the success and roles of others could motivate an aspiring African woman to pursue a career in STEM. A qualitative approach was sought using open online questions and narratives from African women leaders about their roles and career success in STEM. Data were collected from the western, eastern, northern, and southern regions of Africa from participants who held STEM leadership positions, such as directors, deans, and chief officers. The participants were 42 women representing 12 African nations. The narratives of these women leaders' tones and life experiences were analyzed through content analysis. The narratives of these women leaders' tones and life experiences were analyzed in search of recurring patterns and themes. Successful leadership in STEM requires balancing career and family life, setting goals, solving problems, being open to innovative ideas, embracing diversity, collaborating, and having knowledge of STEM research and mentoring skills. Using the achievements and roles of others could inspire future African women to pursue careers in STEM.