The study determined the self-reported Zoom exhaustion and fatigue (ZEF) levels of physical education teacher education (PETE) students in the Philippines who are attending a flexible learning setup (i.e., synchronous and asynchronous learning) offered by their university as a solution to continue classes during the coronavirus disease (COVID)-19 pandemic. Utilizing a cross-sectional comparative research design, the study indicates that PETE students were very tired and exhausted both in general and visually after a series of video conferencing within a semester. Furthermore, they were socially-, motivationally-, and emotionally- moderately tired and exhausted. It was observed that students in the PETE program experienced moderate to very tired and exhausted levels of fatigue whenever they participated in synchronous online classes, such as attendance at a video teleconferencing platform. Exploration of how specific mental aspects relate to their general health with regard to their culture and habits is worth exploring, either for students, teachers, or professionals in general.