Previous studies on spouses of international students do not explore how F-2 visa regulations preventing them from working and becoming full-time students affect their social integration and building social networks. This ethnographic research about 16 formerly employed female spouses of international students in Central University aims to fill this gap, inspired by Holmes's Structural Vulnerability concept (2011), which suggests shifting attention from immigrants themselves to structural powers in order to detect what endangers immigrants' well-being. Through a multimethod approach, this article shows that F-2 visa regulations limit social integration and building social networks of the participants due to their F-2 visa regulations, and consequently affect their self-esteem, mental health, loneliness, and family relationships of the participants, despite the Central University and related/local offices efforts in integrating them in the society.