Chinese international students' well-being is an important part to notice with the rapid number of Chinese international students (CIS) in the U.S. and the increasing number of depressions in college. A systematic review of articles using analytical methods was conducted following the PRISMA guidelines. 1600 studies were initially reviewed from EBSCO, ProQuest, etc. After examining inclusive and exclusive criteria, 30 studies were included in the full review. 19 psychological factors associated with CIS's well-being were found. Results showed that social support is positively associated with CIS's well-being and is correlated with acculturative adjustment for improving psychological well-being. This research revealed the importance of considering cultural psychology in mental health professions, such as acculturation, language issues, and social support. When this population reports depression, anxiety, or academic stress symptoms, mental health providers need to be aware of these impacts and provide psychoeducation for counseling services in the U.S. college. [Note: The page range (529-551) shown on the PDF is incorrect. The correct page range is 529-550.]