ERIC Number: EJ1444866
Record Type: Journal
Publication Date: 2023-Jul
Pages: 7
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: EISSN-1938-1328
Hands-On Approach to Structure Activity Relationships of Substituted MIL-101(Fe)-X Nanozymes: Synthesis, Characterization, and Hammett Analysis
Jingyu Wang; Jiangjiexing Wu; Xiaowei Luo; Xiyang Han; Hao Tian; Rongxin Su
Journal of Chemical Education, v100 n7 p2755-2761 2023
A comprehensive laboratory-style teaching activity involving the synthesis, characterization, and analysis of structure-activity relationships of metal-organic framework (MOF) nanozymes was developed specifically for undergraduates at Tianjin University. The students acquired familiarity with the general approach in synthesizing MOFs by solvothermal method using substituted MIL-101(Fe)-X (MIL is an acronym for Materials of Institute Lavoisier). Several modern characterization methods were taught, including powder X-ray diffraction and fluorescence spectroscopy for assessing MIL-101(Fe)-X crystal structures and superoxide dismutase (SOD)-like activities. In particular, students were guided by the instructor to investigate the relationship between structural differences in MOFs caused by ligand changes and their SOD-like activities. The Hammett relationships were later demonstrated to be an accurate method of quantifying structure-activity relationships of MIL-101(Fe)-Xnanozymes. By participating in this laboratory experience, students are able to improve their scientific thinking, practical abilities, and teamwork. Additionally, a fundamental principle of material design can be conveyed to undergraduates based on the structure-activity relationship, thereby deepening their understanding of nanozymes and the course's content.
Descriptors: Foreign Countries, Undergraduate Students, Chemistry, Science Instruction, Laboratory Experiments, Hands on Science, Synthesis, Molecular Structure, Spectroscopy, Scientific Literacy, Cooperative Learning, Inorganic Chemistry
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: China
Grant or Contract Numbers: N/A