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ERIC Number: EJ1444301
Record Type: Journal
Publication Date: 2023-Aug
Pages: 9
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: EISSN-1938-1328
Application of Electrochemical Chlorination Reaction in Organic Laboratory Course
Jinkun Fan; Yujie Li; Yiting Wei; Feng Liu; Dadong Lu; Tao Ye; Jie Dai; Xu Cheng
Journal of Chemical Education, v100 n8 p3008-3016 2023
The chlorination reaction of aromatic compounds is highly important for the synthesis of pharmaceutical products. As the most common chlorination reagent, chlorine is restricted from undergraduate laboratory experiment training due to its toxicity. In this work, we reported the chlorination of aromatic compounds with chlorine generated from the paired electrolysis of N-chlorosuccinimide. The chlorine in this reaction is produced and consumed in an on-demand manner, ensuring the safety of the reaction, workup, and purification. The reaction is evaluated with 5 undergraduate students with reproducible results and conveys the basic concepts of electrochemical organic synthesis and green synthesis to these students.
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A