Background: Health coaching sessions that incorporate goal setting may help improve college students' health behaviors. Purpose: This study examined whether specific goal-setting practices moderated changes in health behaviors during an online wellness intervention in college students. Methods: Participants were 90 college students recruited from one US university. The intervention was a one-hour virtual one-on-one health coaching session where participants set two goals for either physical activity (Metabolic Equivalent Task (MET)-minutes or MET-minutes), nutrition, sleep, or stress management. Self-reported baseline behaviors were collected, and follow-up surveys were completed at 6- and 12-weeks. Mixed effects models examined behavior change outcomes across the follow-up timepoints while testing the moderating effect of goal setting using interactions. Results: The Goal×Time interaction was significant for moderate MET-minutes at 1st follow-up (b = 443, p = 0.003), and for total MET-minutes at the 2nd follow-up (b = 717, p = 0.047). The Goal×Time interaction was also significant for stress management at 1st follow-up (Odds Ratio = 7.3, p = 0.042). Discussion: Participants who set physical activity and stress management goals had significantly higher physical activity and utilized more stress management techniques. Translation to Health Education Practice: The use of specific goal-setting strategies for physical activity and stress management is recommended during online health coaching sessions. A AJHE Self-Study quiz is online for this article via the SHAPE America Online Institute (SAOI) http://portal.shapeamerica.org/trn-Webinars.