This contribution proposes a fourth paradigm for twenty-first century careers adopting a sustainable development framework. First the evolution of the career development field through three paradigms (individual differences, individual development, life design) of career science and practice is offered. Then sustainable development as a fourth paradigm is introduced considering two pillars, Sustainability Science including contributions from the psychology of sustainability and sustainable development, and Human Security Psychology. Enhancing the well-being of individuals and environments, the fourth paradigm asks for redefining sustainable careers, career intervention, and skills for career counselors. Decent work, decent lives and healthy lives issues are included.