In this 21st century, learners are required to be able to adapt to new challenges so that they can solve problems in the real world. This poses challenges in learning, especially online learning, which will continue to grow. This research aims to produce worksheets for prospective teachers using the Interactive Case-Based Learning (ICBL) model assisted by the Cublend Application and oriented to quality mathematical literacy skills in terms of validity, practicality and effectiveness. The R&D development model consists of initial investigation, design, realization, validation & Revision, implementation, and evaluation. The instruments used were an expert validation questionnaire, a student response questionnaire and a mathematical literacy test. The results showed that: (1). Student worksheets using the ICBL model assisted by Cublend App (ICBL-Cublend App) are declared valid and very feasible to use based on expert assessment with a V coefficient of 0.82 and a percentage of 85.50%; (2). Student worksheets using the ICBL-Cublend App model are classified as practical based on the responses of prospective mathematics teacher students with a percentage of 79% (3). Applying the ICBL-Cublend App model effectively improves mathematical literacy skills and significantly influences prospective mathematics teachers' mathematical literacy skills. This study's results imply that students based on the ICBL-Cublend App model can be used as an alternative learning model in university teacher professional development programs.