This study examined the associations between race, ethnicity, help-seeking behavior and perceptions of mental health treatment among college students with depression. This cross-sectional study included pooled data from the Fall 2018 and Spring 2019 semesters for n = 654 students from one large, public university. Baseline surveys were administered to undergraduate students at the beginning of each semester. Findings indicated that Asian students with depression have a 77% increased odds (aOR = 1.77, 95% CI: (1.17, 2.68), p value = 0.007) of seeking help compared to White students with depression. Asian students with depression have two times the odds of regretting not seeking help compared to White students (aOR = 2.00, 95% CI: (1.05, 3.89), p value = 0.03) while Hispanic students with depression have 1.72 times the odds of regretting not seeking help compared to White students (aOR = 1.72, 95% CI: (0.94, 3.16), p value = 0.079). Asian race modified the effect of general anxiety on help-seeking behavior, reducing the odds of help-seeking by 53% (interaction OR: 0.47 (95% CI: (0.20, 1.10), p value = 0.08). Findings show that the psychosocial landscape of Asian minorities among students with depression is changing; future research should focus on these shifting attitudes to encourage help-seeking behavior and tailor treatment.