Emerging research suggests that first-generation queer and trans (QT) students experience disproportionate discrimination in schooling leading to disengagement early on in their educational trajectories. Although labeled as "at risk", first-generation QT students are actually more cognitively engaged in academics than their cisgender and heterosexual peers. Administrators, teachers, counselors, and guardians (validating agents) have an ethical responsibility to foster inclusive schooling contexts for first-generation QT students. This study examines how validating agents impact first-generation QT students' school engagement, high school GPA, and postsecondary enrollment. We posit a queer theorizing of the ecological validation model of student success and through principles of QuantCrit, we examine the High School Longitudinal Study of 2009 through a path analysis. Our results reveal that both talking to parents about college and high school GPA had a positive association with college enrollment for first-generation QT students. We provide recommendations for future research and practice that demand further exploration of first-generation QT students.