Stereoselective reduction of ketones to alcohols using baker's yeast is a classic experiment in the undergraduate laboratory. Here we illustrate the reduction of racemic ethyl 2-fluoro-3-oxobutanoate to the corresponding alcohol using a set of four commercially available ketoreductases (KREDs). The reaction sets two stereocenters with four stereoisomers possible, with different KREDs selecting for different stereoisomers. Products are characterized by [superscript 1]H and [superscript 19]F NMR spectroscopy to establish diastereomeric and enantiomeric excess. Students learn about dynamic reductive kinetic resolution (DYRKR) and perform NMR Mosher ester analysis for stereochemical assignments.