ERIC Number: EJ1440787
Record Type: Journal
Publication Date: 2024-Mar
Pages: 15
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1087-0547
EISSN: EISSN-1557-1246
Preclinical Models of Attention Deficit Hyperactivity Disorder: Neurobiology, Drug Discovery, and Beyond
Deirdre M. McCarthy; Thomas J. Spencer; Pradeep G. Bhide
Journal of Attention Disorders, v28 n5 p880-894 2024
Objective: We offer an overview of ADHD research using mouse models of nicotine exposure. Method: Nicotine exposure of C57BL/6 or Swiss Webster mice occurred during prenatal period only or during the prenatal and the preweaning periods. Behavioral, neuroanatomical and neurotransmitter assays were used to investigate neurobiological mechanisms of ADHD and discover candidate ADHD medications. Results: Our studies show that norbinaltorphimine, a selective kappa opioid receptor antagonist is a candidate novel non-stimulant ADHD treatment and that a combination of methylphenidate and naltrexone has abuse deterrent potential with therapeutic benefits for ADHD. Other studies showed transgenerational transmission of ADHD-associated behavioral traits and demonstrated that interactions between untreated ADHD and repeated mild traumatic brain injury produced behavioral traits not associated with either condition alone. Conclusion: Preclinical models contribute to novel insights into ADHD neurobiology and are valuable tools for drug discovery and translation to benefit humans with ADHD.
Descriptors: Models, Attention Deficit Hyperactivity Disorder, Smoking, Animals, Prenatal Influences, Correlation, Drug Use, Drug Therapy, Behavior Patterns, Brain, Injuries, Genetics, Brain Hemisphere Functions, Neurological Organization, Medical Research, Drug Abuse
SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://bibliotheek.ehb.be:2993
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: National Institutes of Health (NIH) (DHHS); US Department of Defense (DOD)
Authoring Institution: N/A
Grant or Contract Numbers: RO1DA020796; R15DA043848; W81XWH1210510