Artificial intelligence (AI) and virtual reality (VR) are interconnected, integrated technologies that help to visualize AI systems and increase the fidelity and interactivity of VR in the educational field. Using VR and AI technology, teachers can promote thinking and knowledge in learning. This research aims to analyze and highlight several research publications that examine the use of VR to improve ES students' twenty-first-century skills. The systematic literature review method conducts research to identify, evaluate, explore, and interpret all research results relevant to the research questions. This research has identified the potential of applying AI to twenty-first-century learning to revolutionize education through universal access, adaptation, and intelligent content creation for understanding concepts effectively. VR has a positive impact on students and teachers, as well as increasing motivation, understanding, and effectiveness in learning activities. We discovered that integrating VR into twenty-first-century learning among ES students is associated with increased engagement and motivation, better learning outcomes, and improved creativity and critical thinking skills. The results of this research provide constructive insight for teachers to improve the skills of ES students in the twenty-first century.