The use of Artificial Intelligence (AI) in education is transforming various dimensions of the education system, such as instructional practices, assessment strategies, and administrative processes. It also plays an active role in the progression of science education. This systematic review attempts to render an inherent understanding of the evidence-based interaction between AI and science education. Specifically, this study offers a consolidated analysis of AI's impact on students' learning outcomes, contexts of its adoption, students' and teachers' perceptions about its use, and the challenges of its use within science education. The present study followed the PRISMA guidelines to review empirical papers published from 2014 to 2023. In total, 74 records met the eligibility for this systematic study. Previous research provides evidence of AI integration into a variety of fields in physical and natural sciences in many countries across the globe. The results revealed that AI-powered tools are integrated into science education to achieve various pedagogical benefits, including enhancing the learning environment, creating quizzes, assessing students' work, and predicting their academic performance. The findings from this paper have implications for teachers, educational administrators, and policymakers.