As substance use disorders (SUDs) continue to rise in the wake of the COVID-19 pandemic, occupational therapy practitioners are in a unique position to help individuals seek immediate screening, brief intervention, and referral for treatment upon first entry in a healthcare setting. Occupational therapy practitioners have helped individuals overcome SUDs since almost the beginning of the profession, however, there is a paucity of literature on entry-level practitioners' preparedness for such work. The purpose of this study was to evaluate the effectiveness of an entry-level occupational therapy curriculum module on Screening, Brief Intervention, and Referral to Treatment (SBIRT), a universal public health approach by the U.S. Department of Health and Human Services taught to occupational therapy students. Student participants were provided with classroom education, online learning materials, an interactive case study, an interprofessional education event, and debriefing with community members in recovery. These educational experiences demonstrated significant increases in pre-and post-score means of participants' knowledge, confidence, competence, attitudes on SUDs, and readiness for conducting an SBIRT protocol. This study aims to illustrate how SBIRT educational practices can empower future practitioners to be effective agents of change in addressing substance use disorders in an evolving healthcare landscape.