This interdisciplinary, conceptual analysis addresses the nature and benefits of artistic processes in learning and work. While recognizing various forms of artistry, the emphasis is on visual-spatial thinking. The benefits of this kind of thinking in academic and professional activities include the simplification of massively complex writing, improvement of psychological functioning, and the magnification of creative work in various professions, especially in science, technology, engineering, and mathematics (STEM) fields. Visual-spatial thinking also is a strength that often helps twice-exceptional individuals overcome their learning difficulties. Several thinking and learning strategies are explored, including visual data animation, concept cartooning, visual metaphor, and musical translation of written material. Some ways that visual-spatial thinking can help overcome the problems generated by dogmatic school reform also are scrutinized.