To explore and explain teaching and learnign issues in a current veterinary infectious disease course, the author proposed the concept of blended learning with a BOPPPS (bridge-in, objective, pre-test, participation learning, post-test, and summary) teaching model (BL-BOPPPS) based on the background of 'Internet plus education'. The study put blended learning (including 'flipped classroom' and the application of 'Rain Classroom' and 'presentation-assimilation-discussion (PAD)') combined with the BOPPPS online and offline model into practice and summarised the teaching effects and reflections that strengthened participatory learning and students' independent learning, thinking and innovation skills, in order to develop them as lifelong learners. This study also aims to provide a new theoretical basis and reference for teaching reform of veterinary infectious disease.