Despite the studies on protean career attitude in the career management literature, career sustainability and its potential outcomes have been subjected to study with limited empirical evidence. With this context, this study propounds a conceptual model connecting protean career orientation and perceived employability with career sustainability. Besides, sequentially, we posit that lifelong learning and proactive skill development mediate the relationship between protean career orientation and perceived employability. To establish the relationship, this study gathered data from Italy and Cyprus. Structural equation modelling was performed using the data collected. The results indicated serial mediation paths through which protean orientation impacts career sustainability.