Although vaccination requirements have been a mainstay of university admissions, the recent shift in vaccination and other preventative measures to reduce the spread of COVID-19 has been met with resistance. Reviewing the vaccination literature, there has been an apparent shift in support for university vaccinations, which is largely a result of the politicized climate surrounding the COVID-19 pandemic. Using a mixed-methods analysis, this study examines how type of institution and location variables affect public and private universities implementation of vaccination mandates and other preventative measures. Data indicate that, similar to other studies, politics matter and higher institutions are finding themselves at odds with state governments in which campus and community safety is not the primary concern.