To determine factors affecting successful research and publication among medical students, a cross-sectional survey study was carried out at four Thai medical schools during 2018-2022. Medical students who had previously performed research under research advisors' supervision and their research advisors were included. There were 120 participants, 78 medical students and 42 research advisors. The most common problems reported by the students were student's lack of knowledge of research design (78%) and research topic (53%), while the most common problems reported by the advisors were student's lack of knowledge of research topic (55%) and how to prepare documents for ethics committee approval (48%). The promoting factors for research success commonly reported by the students and advisors were "an advisor helps with protocol writing and reviewing the manuscript", "research teaching in the curriculum", "provision of an example of a written ethics committee protocol", and "arranging a special session so that advisors can talk to students about their research of interest". Among the 78 participating students, 20 (26%) had successfully published their research in journals. These 20 students were more likely than those without publications to be from an institute that had a special research project or conference for medical students (20% vs. 0%,) and to suggest that teaching protocol writing helped in promoting research success (70% vs. 43%). These findings suggest that teaching research, a special research project or conference for medical students, and faculty development of research advising could potentially increase the success rate of students' research publications.